Nanocrystals, compositions, and methods that aid particle transport in mucus
US9737491B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 17, 2016 |
| Grant date | Aug 22, 2017 |
| Priority date | — |
| Expiry date | Nov 17, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/0089
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.