Methods for enhancing hematopoietic stem/progenitor cell engraftment
US9737567B2 · kind B2 · utility
1Cited by
20References
19Claims
0Family size
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Key dates
| Filing date | Apr 21, 2015 |
| Grant date | Aug 22, 2017 |
| Priority date | — |
| Expiry date | Jul 6, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/999
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using farnesyl compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.