Alpha/beta-polypeptide analogs of glucagon-like peptide-1

US9738697B2 · kind B2 · utility

Assignees

• Wisconsin Alumni Research Foundation · US
• President and Fellows of Harvard College · US

Inventors

• Samuel H. Gellman · Madison, US
• Lisa M. Johnson · Glendale, US
• Alan Attie · Madison, US
• Mark Keller · McFarland, US
• Alan Saghatelian · San Diego, US

Key dates

• Filing date: Jun 23, 2014
• Grant date: Aug 22, 2017
• Expiry date: Jul 24, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are peptide analogs of glucagon-like peptide 1 (GLP-1) that retain agonist activity, but are more resistant to proteolytic degradation than native GLP-1. In the analogs, at least one α-amino acid found in the native GLP-1 is replaced with a β-amino acid residue, which may or may not be cyclically constrained. Pharmaceutical compositions containing the analogs are described, as are methods to treat diabetes, and methods to make proteolytically resistant GLP-1 analogs.