Patent · US Active

Generating image-based diagnostic tests by optimizing image analysis and data mining of co-registered images

US9741112B2 · kind B2 · utility

1Cited by

0References

20Claims

0Family size

Assignee

Definiens GmbH · DE

Inventors

Ralf Schoenmeyer · Gilching, DE
Gerd Binnig · Richterswil, CH
Guenter Schmidt · Leun, DE

Key dates

Filing date	Sep 10, 2015
Grant date	Aug 22, 2017
Priority date	—
Expiry date	Apr 27, 2036

Classification

Technology area (CPC G)Physics
CPC primaryG06T2207/30024
WIPO fieldComputer technology
WIPO sectorElectrical engineering

Abstract

A method for generating an image-based test improves diagnostic accuracy by iteratively modifying rule sets governing image and data analysis of coregistered image tiles. Digital images of stained tissue slices are divided into tiles, and tiles from different images are coregistered. First image objects are linked to selected pixels of the tiles. First numerical data is generated by measuring the first objects. Each pixel of a heat map aggregates first numerical data from coregistered tiles. Second objects are linked to selected pixels of the heat map. Measuring the second objects generates second numerical data. The method improves how well second numerical data correlates with clinical data of the patient whose tissue is analyzed by modifying the rule sets used to generate the first and second objects and the first and second numerical data. The test is defined by those rule sets that produce the best correlation with the clinical data.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.