Crafting of cartilage
US9744043B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 16, 2007 |
| Grant date | Aug 29, 2017 |
| Priority date | — |
| Expiry date | Aug 13, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/06
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention is directed to producing a shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. The invention relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.