Methods of promoting neuronal outgrowth by gypican 2 that binds to receptor protein tyrosine phosphatase sigma

US9744188B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• The Chancellor, Masters and Scholars of the University of Oxford · GB

Inventors

• John Flanagan · Berkeley, US
• Yingjie Shen · Hayward, US
• Edith Yvonne Jones · Felton, GB
• Alexandru Radu Aricescu · Felton, GB
• Charlotte Hannah Coles · Bonn, DE

Key dates

• Filing date: Feb 17, 2012
• Grant date: Aug 29, 2017
• Expiry date: Feb 17, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase δ (RPTPδ), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTPδ and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTPδ. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTPδ. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.