Herpes simplex virus (HSV) with modified tropism, uses and process of preparation thereof
US9744199B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Sep 24, 2015 |
| Grant date | Aug 29, 2017 |
| Priority date | — |
| Expiry date | Sep 24, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.