Functionalized liposomes useful for the delivery of bioactive compounds

US9744247B2 · kind B2 · utility

Assignees

• Consejo Superior de Investigaciones Cientificas (CSIC) · ES
• FUNDACIÓ PARC CIENTÍFIC DE BARCELONA · ES
• CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED · ES
• FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) · ES
• UNIVERSITAT DE BARCELONA · ES
• FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON—INSTITUT DE RECERCA · ES
• UNIVERSITAT AUTÓNOMA DE BARCELONA · ES

Inventors

• Leonor Ventosa Rull · Barcelona, ES
• Jaume Veciana Miró · Barcelona, ES
• Ingrid Cabrera Puig · Güines, CU
• Elisa Elizondo Saez De Vicuña · Barcelona, ES
• Marta Melgarejo Diaz · Badalona, ES
• Miriam Royo Exposito · Barcelona, ES
• Fernando Albericio Palomera · Barcelona, ES
• Daniel Pulido Martinez · Viladecans, ES
• Santiago Sala Vergés · Bellaterra, ES
• Jose Luis CORCHERO NIETO · Granollers, ES
• Simón SCHWARTZ NAVARRO · Cardedeu, ES
• Ibane Abasolo Olaortua · Barcelona, ES
• Antonio Pedro Villaverde Corrales · Barcelona, ES

Key dates

• Filing date: Jun 28, 2013
• Grant date: Aug 29, 2017
• Expiry date: Jun 28, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2982
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.