Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto

US9745270B2 · kind B2 · utility

Assignee

• Arena Pharmaceuticals, Inc. · US

Inventors

• Marlon Carlos · Chula Vista, US
• Weitong Dong · Shanghai, CN
• Mark Macias · San Diego, US
• Suzanne Michiko Sato · San Diego, US
• Lee Alani Selvey · Poway, US

Key dates

• Filing date: May 2, 2016
• Grant date: Aug 29, 2017
• Expiry date: May 2, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea (Compound I), crystalline forms and solvate forms thereof; and compositions comprising 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea, crystalline forms and solvate forms thereof prepared by processes as described herein.