5-substituted indazole-3-carboxamides and preparation and use thereof

US9745271B2 · kind B2 · utility

Assignee

• Samumed, LLC · US

Inventors

• John Hood · San Diego, US
• Sunil Kumar KC · San Diego, US
• David Mark Wallace · San Diego, US
• Gopi Kumar Mittapalli · San Diego, US
• Brian Joseph Hofilena · San Diego, US
• Chi Ching Mak · San Diego, US
• Venkataiah Bollu · San Diego, US
• Brian Walter Eastman · San Diego, US

Key dates

• Filing date: Mar 20, 2015
• Grant date: Aug 29, 2017
• Expiry date: Mar 20, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, fibrotic disorders, cartilage (chondral) defects, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, and neurological conditions/disorders/diseases linked to overexpression of DYRK1A.