Compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient
US9745280B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Jul 22, 2016 |
| Grant date | Aug 29, 2017 |
| Priority date | — |
| Expiry date | Jul 22, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound inhibiting Hsp90 and a pharmaceutical composition including the same as an active ingredient are described, which compound is represented by formula 2 and suppresses the expression of Hsp90, inhibits the accumulation of HIF-1α, the Hsp90 client protein, and efficiently inhibits the activation of VEGF. The compound displays low cytotoxicity and can be effectively used as an active ingredient of an anti-cancer agent, a diabetic retinopathy treating agent, and an anti-arthritic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.