Macrocycles as factor XIa inhibitors
US9745313B2 · kind B2 · utility
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10Claims
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Assignee
Inventors
Key dates
| Filing date | Aug 25, 2016 |
| Grant date | Aug 29, 2017 |
| Priority date | — |
| Expiry date | Aug 25, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compounds of Formula (I):or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.