Cytotoxic-drug delivering molecules targeting HIV (CDM-Hs), cytotoxic activity against the human immunodeficiency virus and methods of use
US9745334B2 · kind B2 · utility
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47Claims
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Key dates
| Filing date | Mar 15, 2013 |
| Grant date | Aug 29, 2017 |
| Priority date | — |
| Expiry date | Jun 16, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/704
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by introducing cytotoxic moieties to gp120-expressing cells, thereby causing cell death and preventing cell infection and spread of HIV. It is shown that CDM-Hs bind to gp120 and gp-120 expressing cells competitively with CD4, and these compounds cause cell death of HIV-infected cells, thereby decreasing viral infectivity. Compounds and methods are described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.