Ligands for antibody and Fc-fusion protein purification by affinity chromotography IV

US9745339B2 · kind B2 · utility

Assignee

• NOVALIX DEUTSCHLAND GMBH · DE

Inventors

• Holger BITTERMANN · Schriesheim, DE
• Marc Arnold · Longmont, US
• Thomas Neumann · Frankfurt am Main, DE
• Inge Ott · Ketsch, DE
• Kristina Schmidt · Heidelberg, DE
• Renate Sekul · Ladenburg, DE

Key dates

• Filing date: Feb 8, 2013
• Grant date: Aug 29, 2017
• Expiry date: Feb 8, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/2866
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The present invention relates to the use, for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I)L-(Sp)v-Ar1—Am—Ar2   (I)wherein L, SP, Ar1, AM, Ar2 and v are defined herein.