Nucleic acid constructs containing orthogonal site selective recombinases (OSSRs)
US9745587B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 15, 2011 |
| Grant date | Aug 29, 2017 |
| Priority date | — |
| Expiry date | Apr 15, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/8213
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides for a recombinant nucleic acid comprising a nucleotide sequence comprising a plurality of constructs, wherein each construct independently comprises a nucleotide sequence of interest flanked by a pair of recombinase recognition sequences. Each pair of recombinase recognition sequences is recognized by a distinct recombinase. Optionally, each construct can, independently, further comprise one or more genes encoding a recombinase capable of recognizing the pair of recombinase recognition sequences of the construct. The recombinase can be an orthogonal (non-cross reacting), site-selective recombinase (OSSR).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.