Methods and compositions for controlling gene expression by RNA processing

US9745610B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Jennifer A. Doudna · Berkeley, US
• Lei S. Qi · Tianjin, CN
• Rachel E. Haurwitz · Kensington, US
• Adam P. Arkin · San Francisco, US

Key dates

• Filing date: Apr 9, 2014
• Grant date: Aug 29, 2017
• Expiry date: Apr 9, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/50
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.