Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections

US9750795B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• David B. Weiner · Yeadon, US
• Matthew P. Morrow · Yeadon, US

Key dates

• Filing date: Dec 11, 2012
• Grant date: Sep 5, 2017
• Expiry date: Nov 4, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/689
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nucleic acid molecules which encode an MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising the nucleic acid molecules are disclosed. Novel proteins which comprise a MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed are disclosed. Methods of inducing an immune response against MRSA PBP2a are disclosed, as are methods of treating an individual who has been diagnosed with MRSA and methods of preventing MRSA infection in an individual.