Biodegradable medical adhesive and preparation method and use thereof

US9750841B2 · kind B2 · utility

Assignees

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN
• CHENGDU YIPING MEDICAL SCIENCE & TECHNOLOGY CO. LTD · CN

Inventors

• Keliang Liu · Beijing, CN
• Liang-Zhen Xu · Xiamen, CN
• Qingsong Zhang · Jinan, CN
• Dazhen Cai · Beijing, CN
• Qingbin Meng · Lo Wu, CN

Key dates

• Filing date: Oct 31, 2012
• Grant date: Sep 5, 2017
• Expiry date: May 5, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08L2312/00
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure.