Patent · US Active

3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals

US9751858B2 · kind B2 · utility

1Cited by

2References

12Claims

0Family size

Assignee

Sanofi · FR

Inventors

Sven Ruf · Mainz, DE
Josef Pernerstorfer · Wuppertal, DE
Thorsten Sadowski · Frankfurt am Main, DE
Georg Horstick · Frankfurt am Main, DE
Herman Schreuder · Frankfurt am Main, DE
Christian Buning · Frankfurt am Main, DE
Klaus Wirth · Frankfurt am Main, DE

Key dates

Filing date	Apr 27, 2016
Grant date	Sep 5, 2017
Priority date	—
Expiry date	Apr 27, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D307/68
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to compounds of the formula I,wherein Ht, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.