Diaryl[A, G]quinolizidine compound, preparation method therefor, pharmaceutical composition, and uses thereof

US9751882B2 · kind B2 · utility

Assignee

• Kingsound & Partner · CN

Inventors

• Hong Liu · Shanghai, CN
• Xuechu ZHEN · Shanghai, CN
• Haifeng Sun · Suzhou, CN
• Liyuan ZHU · Shanghai, CN
• Wangke Qian · Shanghai, CN
• Leiping Yu · Shanghai, CN
• Zeng Li · Pudong New District, CN
• Shengbin Zhou · Shanghai, CN
• Wenxian Cai · Shanghai, CN
• Hualiang Jiang · Shanghai, CN
• Kaixian Chen · Shanghai, CN

Key dates

• Filing date: May 9, 2013
• Grant date: Sep 5, 2017
• Expiry date: May 9, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a diarylo[a,g]quinolizidine compound of formula (I), enantiomer, diastereoisomer, racemate, mixture, pharmaceutically acceptable salt, crystalline hydrate or solvate thereof; the preparation method thereof, and uses thereof in preparing an experimental model drugs related to dopamine receptors and 5-HT receptors or a medicament for treating or preventing a disease related to dopamine receptors and 5-HT receptors.