Patent · US Active

Preparation of certain [((6BR,10AS)-2,3,6B,7,8,9,10, 10A-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalines and pharmaceutically acceptable salts thereof

US9751883B2 · kind B2 · utility

67Cited by

55References

28Claims

0Family size

Assignee

INTRA-CELLULAR THERAPIES, INC. · US

Inventors

John Charles Tomesch · Succasunna, US
Peng Li · New York, US
Wei Yao · Shanghai, CN
Qiang Zhang · Dalian, CN
James David Beard · New York, US
Andrew S. Thompson · Mountainside, US
Hua Cheng · Plainsboro, US
Lawrence P. Wennogle · Fryeburg, US

Key dates

Filing date	Mar 10, 2016
Grant date	Sep 5, 2017
Priority date	—
Expiry date	Mar 10, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines of Formula 2J, as shown below, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines, such methods comprising the preparation of a Compound of Formula 2G, as shown below, and use of said compound to produce the fused gamma-carbolines of Formula 2J, as defined herein:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.