Methods to modulate acute myeloid leukemia stem/progenitor cell expansion and/or differentiation
US9757378B2 · kind B2 · utility
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Key dates
| Filing date | Apr 4, 2014 |
| Grant date | Sep 12, 2017 |
| Priority date | — |
| Expiry date | Apr 4, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5073
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel methods for modulating acute myeloid leukemia stem/progenitor cell expansion and/or differentiation are disclosed. These methods are based on the use of aryl hydrocarbon receptor (AhR) modulators and/or compounds of formula I or IIScreening assays to identify compounds that may be useful for inhibiting and/or eliminating AML initiating cells using AhR modulators and/or the compounds of formula I or II are also disclosed. The use of pharmaceutically acceptable agonists of the AhR for preventing or inhibiting minimal residual disease (MRD) in an AML patient is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.