Composition comprising an organic diluent and a cellulose ether

US9757465B2 · kind B2 · utility

Assignee

• DOW GLOBAL TECHNOLOGIES LLC · US

Inventors

• Roland Adden · Bad Fallingbostel, DE
• Robert L. Sammler · Midland, US
• Meinolf Brackhagen · Walsrode, DE
• Nicholas S. Grasman · Midland, US
• Oliver Petermann · Hamburg, DE
• Steven J. Guillaudeu · Midland, US

Key dates

• Filing date: Apr 8, 2013
• Grant date: Sep 12, 2017
• Expiry date: Jul 8, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09D101/284
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A liquid composition comprises an organic diluent and at least one cellulose ether having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that hydroxyl groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.29 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The liquid composition can be used for preparing a solid dispersion of an active ingredient in a cellulose ether.