Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery

US9757471B2 · kind B2 · utility

Assignees

• UNIVERSIDAD CATOLICA DE CORCOBA (UCC) · AR
• ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS (APHP) · FR
• CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET) · AR
• Universite Pierre Et Marie Curie (Paris 6) · FR

Inventors

• David Klatzmann · Paris, FR
• Eliane Piaggio · Paris, FR
• Hugo Lujan · San Pedro, AR

Key dates

• Filing date: Jul 5, 2013
• Grant date: Sep 12, 2017
• Expiry date: Jul 5, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compositions for oral delivery and methods of treatment using VSP carriers, such as Giardia sp. variable surface proteins (VSP), to deliver therapeutic agents. VSP drug carriers can be combined with bioactive peptides, e.g., insulin, glucagon, or hGH, and be administered orally or mucosally. VSP carriers are resistant to acidic pHs and to proteolytic degradation and protect therapeutic agents from degradation in the gastrointestinal tract.