Continuous flow process for the preparation of Ingenol-3-mebutate
US9758464B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Apr 10, 2015 |
| Grant date | Sep 12, 2017 |
| Priority date | — |
| Expiry date | Apr 10, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/98
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a continuous process for the preparation of ingenol-3-mebutate by reaction, in solution, of ingenol or ingenol anion and angelic anhydride or an equivalent angelylating agent. The continuous flow process is preferably performed in the presence of a base such as lithium hexamethyl disilazane (LiHMDS) and/or an activating agent such as dicyclohexylcarbodiimide (DCC). Also disclosed is a process for recycling the other reaction products obtained in the continuous process for preparation of ingenol-3-mebutate for formation of ingenol, which can then be recycled to form ingenol-3-mebutate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.