Method for preparing phenyloxymethyl-nitro-imidazole derivatives and use of same
US9758488B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 22, 2012 |
| Grant date | Sep 12, 2017 |
| Priority date | — |
| Expiry date | Dec 24, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/94
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Fexinidazole is prepared according to a method which comprises the following steps: a) reacting 1-methyl-2-hydroxymethyl-5-nitro-imidazole with methanesulfonyl chloride in the presence of a suspension of powdered alkaline carbonate in an anhydrous organic solvent suitable for performing nucleophile substitution reactions; b) adding to the resulting reaction medium a solution of 4-methyl-mercapto-phenol in the same organic solvent as referred to in step a); c) separating fexinidazole from the reaction mixture as its hydrochloride salt and d) converting said hydrochloride salt into fexinidazole and optionally, purifying the latter.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.