3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use

US9758505B2 · kind B2 · utility

Assignee

• iTeos Therapeutics SA · BE

Inventors

• Stefano Crosignani · Nivelles, BE
• Sandra Cauwenberghs · Halle, BE
• Gregory Driessens · Ottignies, BE
• Frederik Deroose · Gentbrugge, BE

Key dates

• Filing date: Feb 11, 2015
• Grant date: Sep 12, 2017
• Expiry date: Feb 11, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compound of Formula Ior pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates to a process for manufacturing compounds of Formula I.