Compositions and methods for targeting type 1 interferon producing cells

US9758585B2 · kind B2 · utility

Assignee

• CSL LIMITED · AU

Inventors

• Gino Luigi VAIRO · Melbourne, AU
• Andrew Donald Nash · Melbourne, AU
• Eugene Maraskovsky · Melbourne, AU
• Nick WILSON · Melbourne, AU
• Samantha J. Busfield · Kelmscott, AU
• Con Panousis · Melbourne, AU

Key dates

• Filing date: Feb 9, 2015
• Grant date: Sep 12, 2017
• Expiry date: Feb 9, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides a method for treating lupus, Sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor α (IL-3Rα) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p DCs) and basophils to which it binds.