Functionalized surfaces and methods related thereto

US9759842B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Colin Kinz-Thompson · New York, US
• Ruben L. Gonzalez, Jr. · Hayward, US
• James Hone · New York, US
• Matteo Palma · London, GB
• Alexander Alexeevich Godarenko · Springfield, US
• Daniel Chenet · Jersey City, US
• Samuel Jonas Wind · White Plains, US

Key dates

• Filing date: Jul 28, 2014
• Grant date: Sep 12, 2017
• Expiry date: Jul 28, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G02B6/107
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The disclosed subject matter provides a nanoaperture having a bottom surface and a side wall comprising gold. A surface of the side wall is passivated with a first functional molecule comprising polyethylene glycol. The bottom surface of the nanoaperture can be functionalized with at least one second molecule comprising polyethylene glycol, for example, a silane-PEG molecule. The second molecule can further include a moiety, such as biotin, which is capable of binding a target biomolecule, which in turn can bind to a biomolecule of interest for single molecule fluorescence imaging analysis. Fabrication techniques of the nanoaperture are also provided.