Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells
US9764018B2 · kind B2 · utility
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12References
20Claims
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Key dates
| Filing date | Aug 18, 2014 |
| Grant date | Sep 19, 2017 |
| Priority date | — |
| Expiry date | Aug 18, 2034 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to bioconjugate vaccines comprising N-glycosylated proteins. Further, the present invention is directed to a recombinant prokaryotic biosynthetic system comprising nucleic acids encoding an epimerase that synthesizes an oligo- or polysaccharide having N-acetylgalactosamine at the reducing terminus. The invention is further directed to N-glycosylated proteins containing an oligo- or polysaccharide having N-acetylgalactosamine at the reducing terminus and an expression system and methods for producing such N-glycosylated proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.