Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use

US9764039B2 · kind B2 · utility

Assignee

• Sutro Biopharma, Inc. · US

Inventors

• Christopher D. Thanos · Tiburon, US
• Ramesh Baliga · Redwood City, US
• Kalyani Penta · Palo Alto, US
• Avinash Gill · Emeryville, US
• Gang Yin · South San Francisco, US
• Erik Zimmerman · Pacifica, US

Key dates

• Filing date: Jul 10, 2014
• Grant date: Sep 19, 2017
• Expiry date: Sep 16, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are antibodies comprising multiple non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use. The antibodies are useful for methods of treatment and prevention, methods of detection and methods of diagnosis.