Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases

US9765037B2 · kind B2 · utility

Assignee

• University of Washington through its Center for Commercialization · US

Inventors

• Wesley C. Van Voorhis · Seattle, US
• Wilhelmus G.J. Hol · Kenmore, US
• Eric T. Larson · Bethel, US
• Dustin J. Maly · Seattle, US
• Ethan Merritt · Seattle, US
• Kayode K. Ojo · Federal Way, US

Key dates

• Filing date: Jul 30, 2012
• Grant date: Sep 19, 2017
• Expiry date: May 30, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either T. gondii calcium dependent protein kinases (TgCDPKs) or C. parvum and C. hominus calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula,wherein the variables X, Y, Z, L, R1, and R3 are defined herein.