Antibody producing non-human mammals
US9765133B2 · kind B2 · utility
7Cited by
33References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 29, 2014 |
| Grant date | Sep 19, 2017 |
| Priority date | — |
| Expiry date | Apr 29, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/56966
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.