Antibody constructs for CDH19 and CD3

US9765157B2 · kind B2 · utility

Assignee

• AMGEN RESEARCH (MUNICH) GMBH · DE

Inventors

• Shouhua Xiao · Foster City, US
• Zheng Pan · Beijing, CN
• Dineli Wickramasinghe · San Francisco, US
• Peter Kufer · Munich, DE
• Patrick Hoffmann · Munich, DE
• Tobias Raum · Munich, DE
• Ralf Lutterbüse · Munich, DE
• Elisabeth Nahrwold · Munich, DE
• Claudia Blümel · Munich, DE

Key dates

• Filing date: Jul 31, 2015
• Grant date: Sep 19, 2017
• Expiry date: Jul 31, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds a human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct in the treatment of melanoma, and a kit comprising the antibody construct.