Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions, and bubble detection using electrodes
US9766197B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 6, 2015 |
| Grant date | Sep 19, 2017 |
| Priority date | — |
| Expiry date | Jan 16, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/3276
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.