Methods and compositions for CNS delivery of arylsulfatase A
US9770410B2 · kind B2 · utility
6Cited by
12References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 25, 2011 |
| Grant date | Sep 26, 2017 |
| Priority date | — |
| Expiry date | Nov 30, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0019
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.