Method for producing a polyglycerol nanogel for the encapsulation and release of biologically active substances

US9770420B2 · kind B2 · utility

Assignee

• FREIE UNIVERSITÄT BERLIN · DE

Inventors

• Rainer Haag · Berlin, DE
• Dirk Steinhilber · Berlin, DE
• Wolfgang Friess · Iffeldorf, DE
• Sarah Küchler · Birkenfeld, DE
• Madeleine Witting · Birkenfeld, DE

Key dates

• Filing date: Sep 5, 2013
• Grant date: Sep 26, 2017
• Expiry date: Oct 28, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y305/01001
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond; transferring the mixture into an organic non-solvent; and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances.