Methods to induce targeted protein degradation through bifunctional molecules
US9770512B2 · kind B2 · utility
43Cited by
8References
42Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 6, 2016 |
| Grant date | Sep 26, 2017 |
| Priority date | — |
| Expiry date | May 6, 2036 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to the targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.