Patent · US Active

Modification of reactivity of bone constructs

US9775862B2 · kind B2 · utility

3Cited by

12References

9Claims

0Family size

Assignee

Warsaw Orthopedic, Inc.

Inventors

Guobao Wei · Milltown, US
Susan J. Drapeau · Cordova, US

Key dates

Filing date	Jan 30, 2012
Grant date	Oct 3, 2017
Priority date	—
Expiry date	Jun 8, 2032

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61L2430/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method of enhancing the binding of growth factors and cell cultures to a demineralized allograft bone material which includes applying ex vivo an effective quantity of an ionic force change agent to at least a portion of the surface of a demineralized allograft bone material to produce a binding-sensitized demineralized allograft bone material and implanting the binding-sensitized demineralized allograft bone material into a host bone. The ionic force change agent may include at least one of enzymes, pressure, chemicals, heat, sheer force, oxygen plasma, supercritical nitrogen, supercritical carbon, supercritical water or a combination thereof. A molecule, a cell culture, or a combination thereof is administered to the binding-sensitized demineralized allograft bone material.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.