Patent · US Active

Thienomethylpiperazine derivatives as inhibitors of soluble epoxide hydrolase

US9776991B2 · kind B2 · utility

0Cited by

2References

2Claims

0Family size

Assignee

Sanofi · FR

Inventors

Maria MENDEZ-PEREZ · Frankfurt am Main, DE
Kristin Breitschopf · Frankfurt am Main, DE
Katrin Lorenz · Frankfurt am Main, DE
Hartmut Strobel · Liederbach, DE
Li Wang · Frankfurt am Main, DE
Alexander Schiffer · Frankfurt am Main, DE
Jochen Goerlitzer · Frankfurt am Main, DE

Key dates

Filing date	Dec 2, 2014
Grant date	Oct 3, 2017
Priority date	—
Expiry date	Dec 2, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D487/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to compounds of the formula (I), wherein R1, R2, R3, R4 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, cardiovascular diseases, inflammatory diseases or could show beneficial effects in pain, dyslipidemia, atherosclerosis wound healing and stroke. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.