TFPI inhibitors and methods of use

US9777051B2 · kind B2 · utility

Assignee

• Baxalta Incorporated · CH

Inventors

• Michael Dockal · Wien, AT
• Hartmut Ehrlich · Paris, FR
• Friedrich Scheiflinger · Wien, AT
• Ulf Reimer · Berlin, DE
• Ulrich Reineke · Berlin, DE
• Thomas Polakowski · Berlin, DE
• Eberhard Schneider · Wolfenbüttel, DE

Key dates

• Filing date: Mar 14, 2013
• Grant date: Oct 3, 2017
• Expiry date: Aug 4, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, and/or treat a blood coagulation disorder in a subject.