Patent · US Active

Long interfering nucleic acid duplexes targeting multiple RNA targets

US9777278B2 · kind B2 · utility

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1References

23Claims

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Assignee

Biomics Biotechnologies, Co., Ltd. · CN

Inventors

Dong Liang · Changzhou City, CN
David Sweedler · Louisville, US
Kunyuan Cui · Bothell, US

Key dates

Filing date	Aug 14, 2015
Grant date	Oct 3, 2017
Priority date	—
Expiry date	Aug 14, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/531
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Long interfering nucleic acid (iNA) duplexes, which are at least 30 nucleotides in length, which have at least one nick or nucleotide gap in the antisense or the sense strands or in both the sense and antisense strands. These long iNA duplexes do not induce an interferon response when transfected into mammalian cells. The antisense strands can target two separate mRNAs or two segments of one mRNA.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.