Method for measurement of thrombocyte function

US9778248B2 · kind B2 · utility

Assignee

• Leibniz-Institut Für Analytische Wissenschaften-ISAS-e.V. · DE

Inventors

• Jonathan West · Albuquerque, US
• Dirk Janasek · Dortmund, DE
• Albert Sickmann · Dortmund, DE

Key dates

• Filing date: Aug 26, 2015
• Grant date: Oct 3, 2017
• Expiry date: Aug 26, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2015/1006
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

With a method for measurement of thrombocyte function, a solution is created, by which the sensitivity of individual thrombocytes can be measured with the least possible apparatus effort, with high throughput, by passing a liquid thrombocyte solution, in which the thrombocytes are present in isolated form, into a microfluidic chamber and brought into contact with at least one stimulant, wherein an electrical field directed transverse to the entry direction of the thrombocyte solution is applied to the chamber, and the movement path of the thrombocytes in the electrical field is observed and evaluated, in such a manner that thrombocytes having a movement path directed in the direction toward the minus pole of the electrical field are classified as non-activated thrombocytes, and thrombocytes having a movement path directed in the direction toward the plus pole of the electrical field are classified as activated thrombocytes.