Decellularized composite tissue bioscaffolds for musculoskeletal tissue interface reconstruction and methods of production
US9782248B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 7, 2012 |
| Grant date | Oct 10, 2017 |
| Priority date | — |
| Expiry date | Jun 11, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L27/3691
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
One aspect of the present invention is a method of producing a decellularized composite tissue bioscaffold for musculoskeletal tissue interface reconstruction by physicochemically treating a musculoskeletal tissue interface isolated from allogeneic sources. In certain embodiments, such musculoskeletal tissue interfaces can also be isolated from xenogeneic sources. The method comprises treatment of the interface with detergents, chemical oxidants and ultrasonic energy, and wash steps in between to remove residual detergents as well as oxidants. The resulting bioscaffold may be freeze-dried or lyophilized, sterilized and aseptically packaged for subsequent use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.