Process for the manufacture of isavuconazole or ravuconazole
US9783508B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Jul 31, 2013 |
| Grant date | Oct 10, 2017 |
| Priority date | — |
| Expiry date | Jul 31, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.