Water soluble 4-azapodophyllotoxin analogs

US9783547B2 · kind B2 · utility

Assignees

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• UNIVERSITE DE PARIS DESCARTES · FR
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS · FR

Inventors

• Guy Chabot · Charenton-le-Pont, FR
• Sylviane Giorgi-Renault · Paris, FR
• Stéphanie Desbene-Finck · Paris, FR
• Philippe Helissey · Villeparisis, FR
• Raphael Labruere · Orsay, FR
• Marlène Testud · Paris, FR
• Daniel Scherman · Paris, FR

Key dates

• Filing date: Jan 15, 2015
• Grant date: Oct 10, 2017
• Expiry date: Jan 15, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D219/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to 4-azapodophyllotoxin analogs of formula (I) in which X, R1, R2, R3, R4 and Ar are as defined in claim 1, preferably a pharmaceutically acceptable salt thereof, optionally in the form of a solvate, a composition comprising said analogs, their use as medicament, in particular for the treatment of cancer, and a process for their preparation.