Patent · US Active

Method for activating Oct4 for induction of pluripotent stem cells

US9783786B2 · kind B2 · utility

0Cited by

0References

19Claims

0Family size

Assignees

UNIVERSITÄTSKLINIKUM JENA · DE
Stefan Wolfl · DE

Inventors

Ralf Mrowka · Jena, DE
Gunter Wolf · Eberdingen, DE
Stefan Wolfl · Jena, DE
Xinlai Cheng · Kaiserslautern, DE

Key dates

Filing date	Jun 29, 2012
Grant date	Oct 10, 2017
Priority date	—
Expiry date	Feb 14, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2506/25
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to a method for inducing pluripotent stem cells, wherein a mammalian cell is contacted with a compound characterized by a general formula 1 wherein R1 is (CH2)mE, with E being CCH or CN and m being 0, 1, or 2, and R2 is selected from F, CI, Br, OR3 and R3, with R3 being selected from H, (CHyF2-y)n CHXF3-X, with n=0 or 1. The invention further relates to stem cells obtained by the method of the invention, and culture media comprising the compound of the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.