Screening method, a kit, a method of treatment and a compound for use in a method of treatment
US9784726B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 8, 2014 |
| Grant date | Oct 10, 2017 |
| Priority date | — |
| Expiry date | Jan 8, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/566
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of screening for a candidate compound for the treatment of a condition involving dysregulation of metabolism in a mammal, said method comprising bringing a compound into contact with at least one population of cells, comprising cells that express mTOR and Akt and that are capable of activating mTORC2 and Akt; determining mTORC2 activity and Akt activity in cells brought into contact with the compound, and identifying the candidate compound based on the determined mTORC2 activity and Akt activity. A kit for use in such a method of. A compound for use in a method of treatment of a condition involving dysregulation of metabolism in a mammal, and a method of treatment of such a condition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.