Methods for determining anti-drug antibody isotypes
US9784748B2 · kind B2 · utility
9Cited by
19References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 17, 2013 |
| Grant date | Oct 10, 2017 |
| Priority date | — |
| Expiry date | Apr 17, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/94
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides assay methods for the determination of one or more anti-drug antibody (ADA) isotypes in a sample. As a non-limiting example, the assays of the present invention are particularly useful for determining different ADA isotypes in samples from ADA-positive patients receiving an anti-TNFα drug such as REMICADE™ (infliximab) or HUMIRA™ (adalimumab). The present invention also provides methods for optimizing therapy and/or reducing toxicity in subjects receiving TNFα inhibitors for the treatment of TNFα-mediated disease or disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.