Protein M-based in vivo diagnostic system and detection method
US9788776B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 22, 2014 |
| Grant date | Oct 17, 2017 |
| Priority date | — |
| Expiry date | Sep 20, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/14546
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A wearable device mounted on a living body can detect an analyte response signal transmitted from tissue in the living body. The tissue contains at particles conjugated to at least one complex of (i) an antibody labeled with a fluorophore, the labeled antibody having a target analyte binding site; and (ii) protein M labeled with a quencher that is complimentary to the fluorophore of the labeled antibody, wherein the labeled protein M competes with the target analytes for the target analyte binding site on the labeled antibody; wherein the fluorophore and quencher are spectrally matched such that there is a detectable change in the fluorescent signal. The analyte response signal is related to interaction of the target analytes with the complexes. A processor can determine a presence or absence of the analytes based on the analyte response signal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.